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FLASH GENE
Symbol ITPKB contributors: mct/npt - updated : 14-11-2018
HGNC name inositol 1,4,5-trisphosphate 3-kinase B
HGNC id 6179
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nuclear export signal that has evolved in the catalytic domain as a substitute for an earlier evolved corresponding N-terminal signal (Nalaskowski 2006)
    • HOMOLOGY
    Homologene
    FAMILY
  • inositol phosphokinase (IPK) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton
    text in the plasma membrane, cytoskeleton and in the endoplasmic reticulum
    basic FUNCTION
  • regulating inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5) P4
  • controls positive selection of T cells and modulates Erk activity (Wen 2004)
  • responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling
  • playing a potential role as direct INSP3 metabolizing enzyme and direct regulator of Ca2+ responses to extracellular signals
  • converting Ins(1,4,5)P3 to inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) (Miller 2007)
  • inhibitor of store-operated Ca2+ channels and crucial regulators of B cell selection and activation (Miller 2007
  • possible function of ITPKA, ITPKB in differentiation of embryonic stem cells
  • dense tubular system protein, that is a major regulator of calcium homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by activated by calmodulin; form B is much more sensitive to calcium/calmodulin than form A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to late onset Alzheimer disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS