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FLASH GENE
Symbol UNC5C contributors: mct/npt - updated : 29-08-2018
HGNC name unc-5 homolog C (C. elegans)
HGNC id 12569
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two immunoglobulin (Ig)-like domains
  • two type 1 thrombospondin motifs
  • DEATH domain
  • ZU5 domain
    • HOMOLOGY
    interspecies homolog to C.elegans Unc5
    homolog to murine Unc5hr
    Homologene
    FAMILY
  • dependence receptor family
  • unc-5 family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in cell migration during cerebellum development
  • inducing repulsion in axon guidance through its cytoplasmic tail, antagonized by NTN1 (netrin 1)
  • may be functioning to promote germ cell apoptosis in the testis
  • playing an important role in spinal accessory motor neuron development (Dillon 2007)
  • plays likely a broad role in dorsal guidance of axons in the developing hindbrain
  • NTN1/DCC/UNC5C chemotropism contributes to axonal confinement within the CNS
  • UNC5A, UNC5B, UNC5C and UNC5D encode dependence receptors that regulate the apoptosis/survival balance
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NTN1 receptor
  • NTN1 binds to DCC and DSCAM mediating axon attraction, and UNC5 mediating axon repulsion
  • DSCAM interacts with UNC5C and this interaction is stimulated by NTN1 in primary cortical neurons and postnatal cerebellar granule cells
  • combination of DSCAM with DCC or UNC5C plays an important role in NTN1-mediated axon attraction or repulsion
  • NTN1-UNC5C/DCC interaction is involved in controlling the interhemispherical projection in a subset of early born, deep layer callosal neurons
  • UNC5A, UNC5B, UNC5C, UNC5D and ADGRL3 can simultaneously bind to FLRT3, forming a trimeric complex, and FLRT3 may form transsynaptic complexes with both ADGRL3 and UNC5
  • disengagement of UNC5C with polymerized TUBB3 plays an essential role in NTN-1/UNC5C-mediated axon repulsion
  • direct coupling of dynamic TUBB3 in microtubules with netrin receptors is required for NTN1-mediated axon guidance, and the interaction of NTN1 repulsive receptor UNC5C with TUBB3 is involved in NTN1 mediated axonal repulsion
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in liver, colon and gastric cancer, and UNC5C has been methylated from the early stages of hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice and this phenotype is identical to that produced by dcc haploinsufficiency and observed after adolescence