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FLASH GENE

Symbol

UNC5C

contributors: mct/npt - updated : 29-08-2018

HGNC name	unc-5 homolog C (C. elegans)
HGNC id	12569

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003728 16 - 3646 NP_003719 - 931 - 2005 15729359

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid         Nervous spinal cord anterior horn     highly Reproductive female system breast mammary gland     Respiratory respiratory tract trachea       Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text

heart

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two immunoglobulin (Ig)-like domains
	two type 1 thrombospondin motifs
	DEATH domain
	ZU5 domain

HOMOLOGY

interspecies	homolog to C.elegans Unc5
	homolog to murine Unc5hr

Homologene

FAMILY	dependence receptor family
	unc-5 family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	involved in cell migration during cerebellum development
	inducing repulsion in axon guidance through its cytoplasmic tail, antagonized by NTN1 (netrin 1)
	may be functioning to promote germ cell apoptosis in the testis
	playing an important role in spinal accessory motor neuron development (Dillon 2007)
	plays likely a broad role in dorsal guidance of axons in the developing hindbrain
	NTN1/DCC/UNC5C chemotropism contributes to axonal confinement within the CNS
	UNC5A, UNC5B, UNC5C and UNC5D encode dependence receptors that regulate the apoptosis/survival balance

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	NTN1 receptor
	NTN1 binds to DCC and DSCAM mediating axon attraction, and UNC5 mediating axon repulsion
	DSCAM interacts with UNC5C and this interaction is stimulated by NTN1 in primary cortical neurons and postnatal cerebellar granule cells
	combination of DSCAM with DCC or UNC5C plays an important role in NTN1-mediated axon attraction or repulsion
	NTN1-UNC5C/DCC interaction is involved in controlling the interhemispherical projection in a subset of early born, deep layer callosal neurons
	UNC5A, UNC5B, UNC5C, UNC5D and ADGRL3 can simultaneously bind to FLRT3, forming a trimeric complex, and FLRT3 may form transsynaptic complexes with both ADGRL3 and UNC5
	disengagement of UNC5C with polymerized TUBB3 plays an essential role in NTN-1/UNC5C-mediated axon repulsion
	direct coupling of dynamic TUBB3 in microtubules with netrin receptors is required for NTN1-mediated axon guidance, and the interaction of NTN1 repulsive receptor UNC5C with TUBB3 is involved in NTN1 mediated axonal repulsion

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in liver, colon and gastric cancer, and UNC5C has been methylated from the early stages of hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice and this phenotype is identical to that produced by dcc haploinsufficiency and observed after adolescence