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FLASH GENE
Symbol UNC5C contributors: mct/npt - updated : 29-08-2018
HGNC name unc-5 homolog C (C. elegans)
HGNC id 12569
Location 4q22.3      Physical location : 96.083.657 - 96.470.361
Synonym name
  • unc-5 homolog 3
  • homolog of C. elegans transmembrane receptor Unc5
    • Synonym symbol(s) UNC5H3
    DNA
    TYPE functioning gene
    STRUCTURE 380.47 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D4S3264 - D4S1557 - UNC5C - D4S2380 - D4S1045 - D4S836 - D4S1283 - D4S452 - D4S1647 - D4S421 - qter
    Authors Ackerman (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3646 - 931 - 2005 15729359
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousspinal cordanterior horn  highly
    Reproductivefemale systembreastmammary gland  
    Respiratoryrespiratory tracttrachea   
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two immunoglobulin (Ig)-like domains
  • two type 1 thrombospondin motifs
  • DEATH domain
  • ZU5 domain
    • HOMOLOGY
    interspecies homolog to C.elegans Unc5
    homolog to murine Unc5hr
    Homologene
    FAMILY
  • dependence receptor family
  • unc-5 family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in cell migration during cerebellum development
  • inducing repulsion in axon guidance through its cytoplasmic tail, antagonized by NTN1 (netrin 1)
  • may be functioning to promote germ cell apoptosis in the testis
  • playing an important role in spinal accessory motor neuron development (Dillon 2007)
  • plays likely a broad role in dorsal guidance of axons in the developing hindbrain
  • NTN1/DCC/UNC5C chemotropism contributes to axonal confinement within the CNS
  • UNC5A, UNC5B, UNC5C and UNC5D encode dependence receptors that regulate the apoptosis/survival balance
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NTN1 receptor
  • NTN1 binds to DCC and DSCAM mediating axon attraction, and UNC5 mediating axon repulsion
  • DSCAM interacts with UNC5C and this interaction is stimulated by NTN1 in primary cortical neurons and postnatal cerebellar granule cells
  • combination of DSCAM with DCC or UNC5C plays an important role in NTN1-mediated axon attraction or repulsion
  • NTN1-UNC5C/DCC interaction is involved in controlling the interhemispherical projection in a subset of early born, deep layer callosal neurons
  • UNC5A, UNC5B, UNC5C, UNC5D and ADGRL3 can simultaneously bind to FLRT3, forming a trimeric complex, and FLRT3 may form transsynaptic complexes with both ADGRL3 and UNC5
  • disengagement of UNC5C with polymerized TUBB3 plays an essential role in NTN-1/UNC5C-mediated axon repulsion
  • direct coupling of dynamic TUBB3 in microtubules with netrin receptors is required for NTN1-mediated axon guidance, and the interaction of NTN1 repulsive receptor UNC5C with TUBB3 is involved in NTN1 mediated axonal repulsion
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in liver, colon and gastric cancer, and UNC5C has been methylated from the early stages of hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice and this phenotype is identical to that produced by dcc haploinsufficiency and observed after adolescence