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FLASH GENE
Symbol SNAPC1 contributors: mct - updated : 16-01-2019
HGNC name small nuclear RNA activating complex, polypeptide 1, 43kDa
HGNC id 11134
Location 14q23.2      Physical location : 62.229.074 - 62.263.145
Synonym name PSE binding factor, gamma subunit
Synonym symbol(s) PTFG, PTFgamma, SNAP43
DNA
TYPE functioning gene
STRUCTURE 34.07 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2684 - 368 - 2012 22966203
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
intracellular,nucleus,nucleolus
basic FUNCTION
  • soluble N ethylmaleimide-sensitive factor-attachment protein receptor, SNARE protein
  • required for transcription of SNRN genes by polymerases II and III
  • role for this protein in both basal and activator-induced transcription
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • small nuclear activating protein complex
  • INTERACTION
    DNA TBP associated factor (TAF) binding to the proximal sequence element PSE
    RNA
    small molecule
    protein
  • binding to TBP
  • role for SNAPC1 as a general transcriptional coactivator that functions through elongating POLR2A
  • SNAPC1 is also able to interact with RB1 and TP53 and might therefore play a role in the regulation of mRNA splicing (UsnRNAs) expression during the cell cycle
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS