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Symbol NCOA1 contributors: mct - updated : 07-05-2019
HGNC name nuclear receptor coactivator 1
HGNC id 7668
Location 2p23.3      Physical location : 24.807.345 - 24.993.568
Synonym name
  • stero
  • d receptor coactivator 1
  • Hin-2 protein
  • PAX3/NCOA1 fusion protein
  • class E basic helix-loop-helix protein 74
  • renal carcinoma antigen NY-REN-52
  • Synonym symbol(s) SRC1, SRCO1, MGC129720, NCoA-1, RIP160, F-SRC-1, KAT13A, MGC129719, MGC129720, bHLHe42, bHLHe74
    TYPE functioning gene
    STRUCTURE 186.23 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - D2S2221 - D2S2170 - D2S2168 - [D2S144 ,D2S171 ] - D2S2144 - D2S2223 - D2S158 - cen
    Text [NCOA1 ]
    Physical map
    LOC388930 2 LOC388930 FLJ14126 2p24.1 hypothetical protein FLJ14126 KBTBD9 2p24.1 kelch repeat and BTB (POZ) domain containing 9 KIAA1240 2p24.1 KIAA1240 protein LOC165324 LOC388931 2 hypothetical gene supported by BX647146 FLJ21945 2p24.1 hypothetical protein FLJ21945 FKBP1B 2p24.1 FK506 binding protein 1B, 12.6 kDa P14 2pter-p25.1 pre-mRNA branch site protein p14 TP53I3 2p24.1-p23.3 tumor protein p53 inducible protein 3 LOC375189 2p24.1 hypothetical protein LOC375189 LOC388932 2 similar to FLJ30851 protein LOC388933 2 LOC388933 ITSN2 2pter-p25.1 intersectin 2 PRO2015 2p24.1 hypothetical protein PRO2015 NCOA1 2p23 nuclear receptor coactivator 1 LOC391356 2 similar to ENSANGP00000018456 MGC11266 2p24.1 hypothetical protein MGC11266 ADCY3 2p23 adenylate cyclase 3 LOC51277 LOC388934 2 LOC388934 LOC388935 2 LOC388935 KIAA0953 2p24.1 LOC388935 POMC 2p23.3 proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) DNMT3A 2p23 DNA (cytosine-5-)-methyltransferase 3 alpha DTNB 2p23-p22 dystrobrevin, beta ASXL2 2p24.1 additional sex combs like 2 (Drosophila)
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 6895 - 1441 - 1997 9223431
  • alsos called SRC1a
  • major isoform to mediate thyroid hormone action
  • 22 - 6952 - 1399 - 1997 9223431
    also called SRC1e
    21 - 6892 150 1440 - 1997 9223431
    alsos called SRC1(-Q)
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Reproductivemale systemtestis   
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    SystemCellPubmedSpeciesStageRna symbol
    ReproductiveSertoli cell
    cell lineage
    cell lines
    at STAGE
  • basic helix-loop-helix (HLH) domain juxtaposed to a stretch of 300 AA with the PAS (Per - ARNT - Sim) domain
  • two receptor interacting domains with the LXXLL domain
  • a C terminal histone acetyltransferase domain
  • p160/steroid receptor coactivator (SRC) family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • possessing an intrinsic histone acetyltransferase activity
  • stimulating gene expression in a hormone dependent fashion by facilitating the assembly of basal transcription factors into a stable preinitiation complex
  • enhancing ligand-dependent and receptor dependent cell-free transcription of chromatin
  • playing a role in potnatal survival and male reproduction
  • controling with NCOA2 energy balance between White and Brown adipose tissues, and involved in the pathogenesis of the obesity
  • essential for the maintenance of bone mass by sex hormones, but not for the catabolic action of glucocorticoid, under both physiological and pathological conditions
  • NCOA1, NCOA2, NCOA3, are not functionally redundant in breast cancer cells because they play gene-specific roles in regulating mRNA and protein expression, and they therefore are likely to make unique contributions to breast tumorigenesis
  • promotes breast cancer invasiveness and metastasis by coactivating ETV4-mediated TWIST1 expression
  • transcriptional coregulator of the glucocorticoid receptor, involved in the sensitivity of CRH regulation by stress-related factors
  • involved in positive and negative regulation of the CRH gene, and an important factor for the adaptive capacity of stress
  • with NCOA3 cooperatively regulate placental morphogenesis and embryo survival
  • NCOA1 and NCOA2 can modulate the expression of the uncoupling protein 3 (UCP3) in an antagonistic manner, and have important metabolic functions in white and brown adipose tissues as well as in the liver
  • regulator in caspase-independent and AIFM1-mediated apoptosis (PMId: 22371500)
  • fetal lungs produce signals to initiate labor when mature and NCOA1/NCOA2-dependent production of SFTPA1B and platelet-activating factor (PAF) is crucial for this process
  • CELLULAR PROCESS nucleotide, transcription, regulation
    signaling hormonal
    a component
    small molecule
  • CREBBP and PCAF, coactivating PPARG
  • coregulator with EP300 of the STAT3 transcriptional activity
  • NCOA2
  • HRMT1L1
  • interact with distinct sites on the NH2-terminal activation domain of MYOD1
  • interact with and to be an essential co-activator for several members of the STAT (signal transducer and activator of transcription) family, including STAT3, the major signal transducer of IL (interleukin)-6
  • interactions from brain with ESR1 and progestin receptor are dependent on ligand, receptor subtype, and brain region to manifest the pleiotropic functional consequences that underlie steroid-regulated behaviors
  • interacting with NR1H3 (coactivator-binding surface of NR1H3, but not that of RXRA, is critically important for physical and functional interactions with NCOA1)
  • interacts directly with AIFM1 in mitochondria and specifically inhibits caspase-independent and AIFM1-dependent apoptosis (PMId: 22371500)
  • cell & other
    Other steroid,thypoid hormone dependent
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    in hematological malignancies
    tumoral   translocation    
    t(2;2)(q35;p23), which generates a fusion protein composed of PAX3 and the nuclear receptor coactivator NCOA1, in alveolar rhabdomyosarcoma
    Variant & Polymorphism
    Candidate gene
    Therapy target
    intervention of NCOA1 function may provide new strategies to inhibit breast cancer metastasis
    diabetemetabolic syndrom 
    modulation of the expression and/or activity of NCOA1, NCOA2, represents an attractive way to prevent or treat metabolic disorders