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FLASH GENE

Symbol

GLRA3

contributors: - updated : 11-01-2005

HGNC name	glycine receptor, alpha 3
HGNC id	4328

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q33-q34      Physical location : 175.563.197 - 175.750.465

DNA

TYPE	functioning gene
STRUCTURE	211.00 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed GLRA3L - - 2569 53.9 465 - Nikolic GLRA3K - - 9 - - - Nikolic

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ligand gated ion (a) channel
	two four transmembrane segments

mono polymer

complex

HOMOLOGY

Homologene

FAMILY

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	neurotransmitter-gated ion channel
	binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism	two splice variants GLRA3L

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS