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FLASH GENE
Symbol DPYS contributors: - updated : 07-05-2007
HGNC name dihydropyrimidinase
HGNC id 3013
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
amidohydrolase domain
HOMOLOGY
interspecies homolog to murine Dpys
homolog to C.elegans c47e12.8
Homologene
FAMILY desydropyrimidinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • conversion of 5.6-dihydronacil to 3-ureidopropionate
  • detoxifying 5-fluorouracil
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    pyrimidine metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DPYS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS