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FLASH GENE
Symbol DPYS contributors: - updated : 07-05-2007
HGNC name dihydropyrimidinase
HGNC id 3013
DNA
TYPE functioning gene
STRUCTURE 87.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 2500 56.6 519 - Hamajima
- - - 3800
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
amidohydrolase domain
HOMOLOGY
interspecies homolog to murine Dpys
homolog to C.elegans c47e12.8
Homologene
FAMILY desydropyrimidinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • conversion of 5.6-dihydronacil to 3-ureidopropionate
  • detoxifying 5-fluorouracil
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    pyrimidine metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DPYS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS