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FLASH GENE

Symbol

PPT2

contributors: - updated : 23-06-2006

HGNC name	palmitoyl-protein thioesterase 2
HGNC id	9326

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V2 - - 1772 36 308 - Soymbo, Calero encoded by nine exons (1a to 9) minor - splicing 2000 - - placenta Soymbo some protein (exon 1a to 9) minor 18 exons - splicing 2800 - - ubiquitous Soymbo overlapping with an homolog of latent transforming growth factor beta binding protein (LTBP) minor 18 exons - splicing 7000 - - widely by different from the other forms Soymbo also including LBTP minor 18 exons - splicing 1500 - - - Soymbo

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Reproductive female system ovary     highly Skin/Tegument skin       highly Visual eye       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

palmitoyl-protein thioesterase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	involved in the catabolism of lipid-modified proteins hydrolizing thioesters bonds that link fatty acids to cysteine residues in S-fatty acylated proteins
	not complementing the PPT1 defect in infantile neuronal ceroid lipofuscinosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

knockout mice with neuronal ceroid lypofuscinosis