Selected-GenAtlas references
SOURCE
GeneCards
NCBI Gene
Swiss-Prot
Ensembl
HGNC
UniGene
Nucleotide
OMIM
UCSC
Home Page
FLASH GENE
Symbol
PPT2
contributors: -
updated
: 23-06-2006
HGNC name
palmitoyl-protein thioesterase 2
HGNC id
9326
FLASH GENE
DNA
RNA
EXPRESSION
PROTEIN
DISORDER
ANIMAL & CELL MODELS
DNA
TYPE
functioning gene
STRUCTURE
10.00 kb 9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
Promoter
cytosine-phosphate-guanine/HTF
Binding site
MAPPING
cloned
Y
linked
N
status
confirmed
RNA
TRANSCRIPTS
type
messenger
identification
nb exons
type
bp
product
Protein
kDa
AA
specific expression
Year
Pubmed
V2
-
-
1772
36
308
-
Soymbo, Calero
encoded by nine exons (1a to 9)
minor
-
splicing
2000
-
-
placenta
Soymbo
some protein (exon 1a to 9)
minor 18 exons
-
splicing
2800
-
-
ubiquitous
Soymbo
overlapping with an homolog of latent transforming growth factor beta binding protein (LTBP)
minor 18 exons
-
splicing
7000
-
-
widely by different from the other forms
Soymbo
also including LBTP
minor 18 exons
-
splicing
1500
-
-
-
Soymbo
EXPRESSION
Type
widely
constitutive of
expressed in
(based on citations)
organ(s)
System
Organ level 1
Organ level 2
Organ level 3
Organ level 4
Level
Pubmed
Species
Stage
Rna symbol
Lymphoid/Immune
thymus
highly
Reproductive
female system
ovary
highly
Skin/Tegument
skin
highly
Visual
eye
highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
palmitoyl-protein thioesterase family
CATEGORY
enzyme
SUBCELLULAR LOCALIZATION
intracellular
intracellular,cytoplasm,organelle,lysosome
basic FUNCTION
involved in the catabolism of lipid-modified proteins hydrolizing thioesters bonds that link fatty acids to cysteine residues in S-fatty acylated proteins
not complementing the PPT1 defect in infantile neuronal ceroid lipofuscinosis
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
lipid/lipoprotein
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
knockout mice with neuronal ceroid lypofuscinosis