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FLASH GENE
Symbol MAFK contributors: mct - updated : 30-09-2016
HGNC name v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
HGNC id 6782
Location 7p22.3      Physical location : 1.570.367 - 1.582.678
Synonym name
  • small MAF protein K
  • v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein K
  • basic-leucine zipper transcription factor MafK
  • erythroid transcription factor NF-E2 p18 subunit
  • nuclear factor erythroid-2, ubiquitous (p18)
  • Synonym symbol(s) NFE2U, P18, MGC71717, FLJ32205
    DNA
    TYPE functioning gene
    STRUCTURE 12.31 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3350 17.5 156 - 1998 9763667
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • basic leucine zipper (bZIP) domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to avian musinloaponeurotic fibrosarcoma (v-maf) oncogene
    Homologene
    FAMILY
  • BZIPfamily
  • MAF subfamily
  • small MAF family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • regulating cell differentiation processses and also cellular function
  • JDP2 plays a critical role as a cofactor for the transcription factors NFE2L2 and MAFK in the regulation of the antioxidants and production of reactive oxygen species (ROS)
  • is a novel transcriptional regulator that modulates NFKB1 activity
  • MAFK controls NFKB1 activity via CREBPP-mediated RELA acetylation
  • role of MAFK in osteosarcoma that might be closely linked to the Wnt signaling pathway
  • acts as a dominant negative form of large MAFs
  • its overexpression impairs endocrine development through a regulation of numerous beta-cell-related genes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription factor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BACH1
  • MAFK/NFE2 recruitment was involved in the physical proximity of locus control region (LCR) and active beta-globin genes upon beta-globin gene transcriptional activation
  • TGFB1 induced expression of transcription factors MAFK and BACH1
  • JDP2 associates with NFE2L2 and MAFK (NFE2L2-MAFK) to increase the transcription of antioxidant response element-dependent genes
  • JDP2 bound directly to the ARE core sequence, associated with NFE2L2 and MAFK (NFE2L2-MAFK) via basic leucine zipper domains, and increased DNA-binding activity of the NFE2L2-MAFK complex to the ARE and the transcription of ARE-dependent genes
  • WNT1 regulates the expression of CD36 through TCF4 and PPARG
  • WNT1-induced MAFK expression promotes osteosarcoma cell proliferation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • neurons from an alternative promoter at least in mouse
  • Mafk-transgenic embryos appeared to be disorganized with an inversion of total numbers of insulin+ and glucagon+ cells due to reduced beta-cell proliferation