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FLASH GENE
Symbol TAGLN2 contributors: mct - updated : 22-08-2013
HGNC name transgelin 2
HGNC id 11554
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CH (calponin-homology) domain
  • a calponin-like repeat
    • conjugated Other
    HOMOLOGY
    interspecies homolog to zebrafish SM22alpha
    homolog to rattus Tagln2 (97 pc)
    homolog to murine Tagln2 (96.5 pc)
    intraspecies homolog to transgelin a early marker of smooth muscle differentiation
    Homologene
    FAMILY
  • calponin family
    • CATEGORY unknown/unspecified , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nuclear envelope
    basic FUNCTION
  • actin-binding protein shown to be a tumor suppressor
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • maybe actin binding
  • unphosphorylated TAGLN2 in CDK14-suppressed cells elicited strong actin-binding ability, a mechanism that possibly halts the actin cytoskeleton dynamics
    • cell & other
    REGULATION
    Other acetylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    PTTG1 and TAGLN2 are highly expressed in human pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • cross-section of zebrafish SM22alpha-deficient embryo suggests that SM22alpha may play roles in smooth muscle cell morphology transform