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FLASH GENE
Symbol TAGLN2 contributors: mct - updated : 22-08-2013
HGNC name transgelin 2
HGNC id 11554
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 intestinelarge intestinecolon  
 liver    
 salivary gland   moderately
Lymphoid/Immunespleen    
 thymus    
 tonsils   highly
Reproductivefemale systemuteruscervix moderately
 female systemovary   
 male systemtestis   
 male systemprostate   
Respiratorylung    
Skin/Tegumentskin   moderately
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connectiveadipose  predominantly
Lymphoid    
Muscularsmooth   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CH (calponin-homology) domain
  • a calponin-like repeat
    • conjugated Other
    HOMOLOGY
    interspecies homolog to zebrafish SM22alpha
    homolog to rattus Tagln2 (97 pc)
    homolog to murine Tagln2 (96.5 pc)
    intraspecies homolog to transgelin a early marker of smooth muscle differentiation
    Homologene
    FAMILY
  • calponin family
    • CATEGORY unknown/unspecified , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nuclear envelope
    basic FUNCTION
  • actin-binding protein shown to be a tumor suppressor
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • maybe actin binding
  • unphosphorylated TAGLN2 in CDK14-suppressed cells elicited strong actin-binding ability, a mechanism that possibly halts the actin cytoskeleton dynamics
    • cell & other
    REGULATION
    Other acetylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    PTTG1 and TAGLN2 are highly expressed in human pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • cross-section of zebrafish SM22alpha-deficient embryo suggests that SM22alpha may play roles in smooth muscle cell morphology transform