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FLASH GENE
Symbol POU4F1 contributors: shn - updated : 27-03-2010
HGNC name POU class 4 homeobox 1
HGNC id 9218
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA binding protein
  • POU specific and POU homeo (helix-turn-helix) domains
    • HOMOLOGY
    interspecies ortholog to Pou4f1, Rattus norvegicus
    ortholog to Pou4f1, Mus musculus
    ortholog to pou4f1, Danio rerio
    Homologene
    FAMILY
  • POU family transcription factor
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • activating genes encoding synaptic vesicle proteins
  • stimulating neurite outgrowth
  • overexpression in ND7 neuronal cell can induce neurite outgrowth and the activation of genes encoding synaptic vesicle proteins in the absence of a differentiation-inducing stimulus
  • with POU4F1 are each required for efficient transcription of NTRK1 in primary sensory neurons and and cooperation between these two transcription factors is required for endogenous NTRK1 gene expression and the survival of nociceptive sensory neurons
  • a marker of retinal ganglion cells in naive and axotomized retinas
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text neural development (axonogenesis and synaptogenesis)
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • estrogen receptor, ER (Budhram-Mahadeo et al, 1998)
  • pro-oncoprotein Ewing's Sarcoma protein,
  • small GTP-binding protein Rin
  • ISL1 binds to a known POU4F1-regulated enhancer in the NEUROD4 gene, suggesting a mechanism of interaction between these genes
    • cell & other
    REGULATION
    induced by pro-oncoprotein EWS (Ewing's Sarcoma protein)
    Other expressed with POMC in a subset of adult anterior pituitary cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS