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FLASH GENE

Symbol

POU4F1

contributors: shn - updated : 27-03-2010

HGNC name	POU class 4 homeobox 1
HGNC id	9218

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006237 2 - 3817 NP_006228 - 419 highly expressed in the developing sensory nervous system and in cells of the B- and T-lymphocytic lineages - retinal ganglion cells 1995 7623109

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain           spinal cord         Visual eye retina     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Visual ganglion cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	Rathke pouch at an early stage of pituitary development, expression peaks early in embryo genesis (day 13.5) and in undetectable 14 days after birth

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	DNA binding protein
	POU specific and POU homeo (helix-turn-helix) domains

HOMOLOGY

interspecies	ortholog to Pou4f1, Rattus norvegicus
	ortholog to Pou4f1, Mus musculus
	ortholog to pou4f1, Danio rerio

Homologene

FAMILY

POU family transcription factor

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	activating genes encoding synaptic vesicle proteins
	stimulating neurite outgrowth
	overexpression in ND7 neuronal cell can induce neurite outgrowth and the activation of genes encoding synaptic vesicle proteins in the absence of a differentiation-inducing stimulus
	with POU4F1 are each required for efficient transcription of NTRK1 in primary sensory neurons and and cooperation between these two transcription factors is required for endogenous NTRK1 gene expression and the survival of nociceptive sensory neurons
	a marker of retinal ganglion cells in naive and axotomized retinas

CELLULAR PROCESS	cell life, differentiation
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	neural development (axonogenesis and synaptogenesis)

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	estrogen receptor, ER (Budhram-Mahadeo et al, 1998)
	pro-oncoprotein Ewing's Sarcoma protein,
	small GTP-binding protein Rin
	ISL1 binds to a known POU4F1-regulated enhancer in the NEUROD4 gene, suggesting a mechanism of interaction between these genes

cell & other

REGULATION

induced by

pro-oncoprotein EWS (Ewing's Sarcoma protein)

Other

expressed with POMC in a subset of adult anterior pituitary cells

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS