motifs/domains
| an acidic region |
|
two putative nuclear localizatin signals, one of the two predicted nuclear targeting motifs is required for nuclear localization of BAP1 |
|
a coiled-coil motif, for directly interacting with the zinc fingers of YY1  |
|
HCFC1 binding motif required for interaction with HCF-1N and mediates deubiquitination of HCF-1N by BAP1 |
|
binding domains for BRCA1 and BARD1 |
|
highly charged C-terminal region, and extended C terminus, which may be involved in interaction with other proteins |
|
ubiquitin C-terminal hydrolase (UCH) domain |
SUBCELLULAR LOCALIZATION
| intracellular
|
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
|
| intracellular,cytoplasm,cytosolic
|
|
| intracellular,nucleus,nucleoplasm
|
|
| intracellular,nucleus,chromatin/chromosome
|
|
| intracellular,nucleus,nucleolus
|
| text
| associate with chromatin |
|
BAP1 localizes at the endoplasmic reticulum |
| basic FUNCTION
| ubiquitin carboxy-terminal hydrolase |
|
binding to the BRCA1 RING finger domain and enhancing BRCA1-mediated cell growth suppression |
|
deubiquitinating enzyme having tumor suppressor activity |
|
helps to control cell proliferation by regulating HCFC1 protein levels and by associating with genes involved in the G(1)-S transition) |
|
plays important roles in cell growth and tumor suppression |
|
functionally implicated in numerous biologic processes, including chromatin dynamics, DNA damage response, and regulation of the cell cycle and cell growth |
|
a deubiquitinating enzyme (DUB) involved in the regulation of cell proliferation |
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activates transcription in an enzymatic-activity-dependent manner and regulates the expression of a variety of genes involved in numerous cellular processes |
|
transcriptional coactivator that regulates the expression of genes involved in numerous cellular processes |
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might play an important role in dynamically controlling transcriptional responses that coordinate mitochondrial function |
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role for BAP1 in the regulation of Polycomb target gene expression in malignant pleural mesothelioma cells |
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has an important tumor suppressor function in multiple tissues |
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repressed cell proliferation without causing apoptosis |
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potent tumor suppressor function for BAP1 in myeloid neoplasia |
|
renal cell carcinomas-predisposition gene |
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is a deubiquitinase required for efficient assembly of the homologous recombination (HR) factors BRCA1 and RAD51 at ionizing radiation (IR) -induced foci |
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important role for BAP1 in DSB repair by HR, thereby providing a possible molecular basis for its tumor suppressor function |
|
in the nucleus, BAP1 acts as a chromatin-associated protein exerting its deubiquitinating function through the multiprotein complexes formed with transcription factors and co-factors |
|
functions as part of the DNA damage response (DDR) |
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promoted repair of DNA double-strand breaks, enhancing cell survival after DNA damage |
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nuclear deubiquitinating enzyme to reduce histone 2A ubiquitination (H2Aub) on chromatin |
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BAP1 inhibits tumour development partly through SLC7A11 and ferroptosis |
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glutamylation and deglutamylation of BAP1 modulate hematopoietic stem cells (HSCs) self-renewal and hematopoiesis |
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critical tumor suppressor across multiple cancer types, predisposing to tumor development when mutated in the germline as well as somatically |
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encodes a deubiquitinase enzyme, which plays key roles in cell-cycle regulation, cell death, and differentiation |
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is also involved in several aspects of cellular metabolism, including metabolic homeostasis, glucose utilization, control of ferroptosis, and stress response |
