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FLASH GENE
Symbol MTMR7 contributors: npt/ - updated : 17-09-2004
HGNC name myotubularin related protein 7
HGNC id 7454
Location 8p22      Physical location : 17.154.307 - 17.271.040
Synonym symbol(s) DKFZp781E194, MGC163449, MGC163451
EC.number 3.1.3.-
DNA
TYPE functioning gene
STRUCTURE 115.30 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 3882 75.6 660 - Laporte (1998)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • region similar to the active site of tyrosine phosphatases
  • a double-helical motif similar to the SET interaction domain (SID)
  • a coiled-coil domain
  • HOMOLOGY
    interspecies homolog to murine Mtmr7
    homolog to C.elegans w10d9.3
    intraspecies homolog to myotubularin protein 7
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class myotubularin subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,granule
    text golgi-like granules
    basic FUNCTION
  • protein tyrosine phosphatase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complexing with MTMR9 to dephosphorylate phosphatidyl inositol 3 phosphate in neuronal cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS