SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,vault
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome
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| intracellular,nuclear envelope,lamina
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text
| accumulation of progerin, a truncated form of farnesylated and carboxymethylated prelamin A identified in Hutchinson-Gilford progeria syndrome cells, induces BANF1 recruitment in the nucleus |
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essential component of the nuclear lamina |
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nuclear periphery proteins LMNA, TMPO and BANF1 relocate to the spindle and the cell cortex in mitosis |
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presence of the EMD fraction which associates with mitotic spindle microtubules and centrosomes during mitosis and colocalizes during early mitosis with LMNA, BANF1, and membranes at the mitotic spindle |
basic FUNCTION
| protect retroviral DNA from autointegration |
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required for the integrity of the nuclear lamina and normal progression of S phase in human cells |
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BANF1 and emerin have dynamic roles in genome integrity and might help couple DNA damage responses to the nuclear lamina network |
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DNA-binding protein that interacts directly with histones, lamins and LEM-domain proteins and has roles in chromatin structure, mitosis and gene regulation |
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could mediate prelamin A-induced chromatin effects |
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required to maintain the self-renewal of both mouse and human embryonic stem cells |
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prelamin A involvement in BANF1 nuclear recruitment, suggesting BANF1-prelamin A complex as a protein platform usually activated in prelamin A-accumulating diseases |
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is an essential player of nuclear reformation at the end of mitosis |
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essential component of the nuclear lamina |
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possible roles of BANF1 in regulation of keratinocyte differentiation and proliferation |
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new role for BANF1: remodeling intracellular membranes upon detection of double-stranded DNA (dsDNA) in mammalian cells |
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abundant, highly conserved DNA binding protein |
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LMNA, TMPO and BANF1 are assembled into a protein complex during mitosis in order to regulate assembly and positioning of the mitotic spindle |
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is involved in multiple pathways including mitosis, nuclear assembly, viral infection, chromatin and gene regulation and the DNA damage response |
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contributes to multiple aspects of genome maintenance and intercepts retrovirus, poxvirus, and herpesvirus genomes during infection |