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FLASH GENE
Symbol NR2C1 contributors: mct - updated : 18-08-2011
HGNC name nuclear receptor subfamily 2, group C, member 1
HGNC id 7971
Location 12q22      Physical location : 95.414.059 - 95.467.404
Synonym symbol(s) TR2, TR2-11
DNA
TYPE functioning gene
STRUCTURE 37.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
Nervousbrain   highly Homo sapiens
Reproductivemale systemtestis    Homo sapiens
 male systemprostate   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroid Homo sapiens
Reproductivespermatocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central bipartite (class II) zinc finger
  • a N terminal modulator domain
  • a DNA binding domain
  • a C terminal ligand domain with multiple ligand-binding domains
  • HOMOLOGY
    Homologene
    FAMILY
  • nuclear receptor subfamily 2, group C
  • steroid/thyroid hormone receptor superfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • orphan nuclear receptor
  • NR2C1/NR2C2 directly represses GATA1 transcription in erythroid progenitor cells through an evolutionarily conserved binding site within a well-characterized, tissue-specific GATA1 enhancer
  • possible roles for NR2C1 and NR2C2 in early embryonic development by regulating key genes involved in stem cell self-renewal, commitment, and differentiation
  • play roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with HDAC3 through RID domains
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with HDAC3 and HDAC4
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS