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FLASH GENE
Symbol CYP2C9 contributors: mct - updated : 21-10-2006
HGNC name cytochrome P450, family 2, subfamily C, polypeptide 9
HGNC id 2623
Location 10q24.1      Physical location : 96.698.414 - 96.749.147
Synonym name
  • cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 10
  • microsomal monooxygenase
  • Synonym symbol(s) CPC9, CYP2C, CYP2C10, MGC88320, P450 MP-4, P450 PB-1
    EC.number 1.14.14.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    STRUCTURE 50.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked N status confirmed
    Map cen - CYP2C18 - CYP2C19 - CYP2C9 - CYP2C8 - qter
    Authors Gray et al (95)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 subfamily IIC
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in an NADPH-dependent electron transport pathway and oxidizing a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
  • hydroxylating many xenobiotics inducing phenytoin , S-warfarin, and tolbutamide
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    induced by rifampin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Susceptibility
  • to adverse drug reactions/toxicities when drugs extensively metabolized by CYP2C9
  • to warfarin resistance
  • Variant & Polymorphism SNP , other
  • variability interindividual and ethnic
  • increasing the warfarin resistance
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS