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FLASH GENE
Symbol CYP2A7 contributors: mct - updated : 20-12-2021
HGNC name cytochrome P450, family 2, subfamily A, polypeptide 7
HGNC id 2611
Location 19q13.2      Physical location : 41.381.344 - 41.388.657
Synonym name cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7
Synonym symbol(s) CYP2A, P450-IIA4, CYPIIA7, CPAD, CPA7
EC.number 1.14.14.1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 10.51 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure including five CYP2As,three CYP2b,three CYP25 genes or pseudogene
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1760 49 494 - 1995 7864805
8 - 1607 42 443 - 1995 7864805
deletion of exon 2 including 10bp of intron 1 resulting in an internal deletion
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
Homologene
FAMILY
  • cytochrome P450 subfamily IIA
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • oxidizing xenobiotics
  • monooxygenase activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
    • protein
  • flavoprotein P450 oxidoreductase (POR)
    • cell & other
    REGULATION
    induced by phenobarbital
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in malignant oesophageal cells and colon cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS