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FLASH GENE
Symbol CYP2A6 contributors: mct - updated : 24-08-2010
HGNC name cytochrome P450, family 2, subfamily A, polypeptide 6
HGNC id 2610
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to C.elegans K09A11.3
Homologene
FAMILY
  • cytochrome P450 superfamily IIA
  • cytochrome P450 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • hydroxylating coumarin, and also metabolizing nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals
  • also catalyzing nicotine C-oxidation leading to cotinine formation, a major metabolic pathway of nicotine
  • important hepatic Phase I enzyme that metabolizes approximately 3p100 of therapeutic drugs (Di 2009)
  • plays a major role in the oxidation of nicotine in human liver microsomes (Thorgeirsson 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
    • protein
  • flavoprotein P450 oxidoreductase (POR)
  • interacting with CYP2B6 (Ring 2007)
    • cell & other
    REGULATION
    induced by phenobarbital
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in the poor metabolizer phenotype
    Susceptibility
  • susceptibility factor for nicotine addiction and lung cancer
  • to smoking behavior
    • Variant & Polymorphism other
  • CYP2A6*4C allele had lower risk of tobacco-related lung cancer
  • sequence variants associated with smoking behavior (Thorgeirsson 2010)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS