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FLASH GENE

Symbol

CYP2A6

contributors: mct - updated : 24-08-2010

HGNC name	cytochrome P450, family 2, subfamily A, polypeptide 6
HGNC id	2610

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	cluster
SPECIAL FEATURE	component of a cluster
text	cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies
STRUCTURE	6.91 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (TATA box)
text structure	including five CYP2As, three CYP2b, three CYP25 genes or pseudogene
	SNP in the TATA box impairing promoter activity

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000762 9 - 1775 NP_000753 - 494 - Hoffman (2001)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Nervous brain       moderately Reproductive female system breast mammary gland   highly Respiratory lung       moderately

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

monomer

HOMOLOGY

interspecies

homolog to C.elegans K09A11.3

Homologene

FAMILY	cytochrome P450 superfamily IIA
	cytochrome P450 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic,microsome

basic FUNCTION	hydroxylating coumarin, and also metabolizing nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals
	also catalyzing nicotine C-oxidation leading to cotinine formation, a major metabolic pathway of nicotine
	important hepatic Phase I enzyme that metabolizes approximately 3p100 of therapeutic drugs (Di 2009)
	plays a major role in the oxidation of nicotine in human liver microsomes (Thorgeirsson 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

drug

signaling

oxidative metabolism

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	NADPH, heme

protein	flavoprotein P450 oxidoreductase (POR)
	interacting with CYP2B6 (Ring 2007)

cell & other

REGULATION

induced by

phenobarbital

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

Human Cytochrome P450 (CYP) Allele Nomenclature Committee

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     in the poor metabolizer phenotype

Susceptibility

susceptibility factor for nicotine addiction and lung cancer to smoking behavior

Variant & Polymorphism other	CYP2A6*4C allele had lower risk of tobacco-related lung cancer
	sequence variants associated with smoking behavior (Thorgeirsson 2010)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS