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FLASH GENE
Symbol CYP2A6 contributors: mct - updated : 24-08-2010
HGNC name cytochrome P450, family 2, subfamily A, polypeptide 6
HGNC id 2610
Location 19q13.2      Physical location : 41.349.443 - 41.356.352
Synonym name
  • coumarin 7-hydroxylase/major nicotin oxidase
  • cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 3
  • cytochrome P450(I)
  • xenobiotic monooxygenase
  • flavoprotein-linked monooxygenase
    • Synonym symbol(s) CYP2A3, CPA6, P450C2A, P450PB, CYP2A
    EC.number 1.14.14.1
    DNA
    TYPE cluster
    SPECIAL FEATURE component of a cluster
    text cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies
    STRUCTURE 6.91 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    text structure
  • including five CYP2As, three CYP2b, three CYP25 genes or pseudogene
  • SNP in the TATA box impairing promoter activity
    • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1775 - 494 - Hoffman (2001)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousbrain   moderately
    Reproductivefemale systembreastmammary gland highly
    Respiratorylung   moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to C.elegans K09A11.3
    Homologene
    FAMILY
  • cytochrome P450 superfamily IIA
  • cytochrome P450 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • hydroxylating coumarin, and also metabolizing nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals
  • also catalyzing nicotine C-oxidation leading to cotinine formation, a major metabolic pathway of nicotine
  • important hepatic Phase I enzyme that metabolizes approximately 3p100 of therapeutic drugs (Di 2009)
  • plays a major role in the oxidation of nicotine in human liver microsomes (Thorgeirsson 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
    • protein
  • flavoprotein P450 oxidoreductase (POR)
  • interacting with CYP2B6 (Ring 2007)
    • cell & other
    REGULATION
    induced by phenobarbital
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in the poor metabolizer phenotype
    Susceptibility
  • susceptibility factor for nicotine addiction and lung cancer
  • to smoking behavior
    • Variant & Polymorphism other
  • CYP2A6*4C allele had lower risk of tobacco-related lung cancer
  • sequence variants associated with smoking behavior (Thorgeirsson 2010)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS