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FLASH GENE

Symbol

FOLR2

contributors: mct - updated : 22-12-2017

HGNC name	folate receptor 2 (fetal)
HGNC id	3793

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   in synovial monocytes from the joints of patients with rheumatoid arthritis constitutional     --over   in activated macrophages commonly involved in the pathogenesis of inflammatory and autoimmune diseases constitutional     --low   severe Pre-eclampsia (PE) is associated with decreased placental expression of FOLR2

Susceptibility

to meningomyelocele (MM)

Variant & Polymorphism SNP	rs13908, statistically significant for association to MM

Candidate gene
Marker	FOLR2 positive macrophages in the stroma could serve as a useful indicator of a tumor metastatic potential
	expression of FOLR2 on activated macrophages holds a promising potential for early diagnosis and better analysis of optimal treatment regiments of vascular diseases in association with systemic diseases
	is a marker for M2 regulatory macrophage polarization and indicating that folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages (TAM)
Therapy target
	System Type Disorder Pubmed cancer endocrine pancreas FOLR2 macrophages may be promising a targeting therapy for pancreatic cancer

ANIMAL & CELL MODELS

Folr2 knockout mice