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FLASH GENE
Symbol MMP23A contributors: - updated : 04-05-2004
HGNC name matrix metalloproteinase 23A
HGNC id 7170
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal prosequence lacking the so-called cysteine switch needed for autocatalytic activation
  • a furin recognition motif
  • a catalytic domain containing the zinc binding site
  • a cysteine-rich domain
  • a Ig-like motif
  • a putative transmembrane segment and a short cytoplasmic tail
    • conjugated MetalloP
    HOMOLOGY
    intraspecies paralog to MMP23B
    Homologene
    FAMILY MMP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text cleaved in the Golgi and released as an active enzyme into the extracellular space
    basic FUNCTION
  • regulator in matrix remodeling
  • may be playing a role in enchondral bone formation and in regulation of cranial suture closure
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein binding TIMPs in a 1:1 stoechiometry
    cell & other
    REGULATION
    activated by furin (intracellularly) and proteinases
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL1P36 , DUP1P36
    Susceptibility
    Variant & Polymorphism
    Candidate gene for cranial suture closure in del1p36 and dup1p36 syndromes
    Marker
    Therapy target
    ANIMAL & CELL MODELS