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FLASH GENE
Symbol CBR3 contributors: npt/mct - updated : 10-09-2014
HGNC name carbonyl reductase 3
HGNC id 1549
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies ortholog to murine Cbr3
homolog to C.elegans F54F3.4
intraspecies paralog to CBR1
Homologene
FAMILY
  • short chain dehydrogenase/reductase (SDR) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • carbonyl reductase, NADPH-dependent oxidoreductase
  • catalyze the reduction of many endogenous and xenobiotic carbonyl compounds, including steroids and prostaglandins
  • minor role in xenobiotic metabolism for CBR3
  • its expression is induced under inflammatory conditions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • CBR3 is a new member of the NFE2L2 gene battery
    • INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein
  • target gene of NFE2L2, a cellular sensor of oxidative stress
    • cell & other
    REGULATION
    Other regulated by the master redox switch NFE2L2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to interindividual variability in the disposition of CBR drug substrates
  • to type 2 diabetes and insulin resistance
    • Variant & Polymorphism other
  • common CBR3 V244M polymorphism encodes for CBR3 isoforms with distinctive enzymatic properties
  • rs10483032 in the CBR3 (carbonyl reductase 3) gene, associated with type 2 diabetes
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS