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FLASH GENE
Symbol CBR3 contributors: npt/mct - updated : 10-09-2014
HGNC name carbonyl reductase 3
HGNC id 1549
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
 salivary gland   highly
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
not specificadipocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies ortholog to murine Cbr3
homolog to C.elegans F54F3.4
intraspecies paralog to CBR1
Homologene
FAMILY
  • short chain dehydrogenase/reductase (SDR) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • carbonyl reductase, NADPH-dependent oxidoreductase
  • catalyze the reduction of many endogenous and xenobiotic carbonyl compounds, including steroids and prostaglandins
  • minor role in xenobiotic metabolism for CBR3
  • its expression is induced under inflammatory conditions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • CBR3 is a new member of the NFE2L2 gene battery
    • INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein
  • target gene of NFE2L2, a cellular sensor of oxidative stress
    • cell & other
    REGULATION
    Other regulated by the master redox switch NFE2L2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to interindividual variability in the disposition of CBR drug substrates
  • to type 2 diabetes and insulin resistance
    • Variant & Polymorphism other
  • common CBR3 V244M polymorphism encodes for CBR3 isoforms with distinctive enzymatic properties
  • rs10483032 in the CBR3 (carbonyl reductase 3) gene, associated with type 2 diabetes
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS