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FLASH GENE

Symbol

CBR3

contributors: npt/mct - updated : 10-09-2014

HGNC name	carbonyl reductase 3
HGNC id	1549

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001236 3 - 1128 NP_001227 30 277 - 1998 9740676

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly   salivary gland       highly Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol not specific adipocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

monomer

HOMOLOGY

interspecies	ortholog to murine Cbr3
	homolog to C.elegans F54F3.4

intraspecies

paralog to CBR1

Homologene

FAMILY

short chain dehydrogenase/reductase (SDR) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	carbonyl reductase, NADPH-dependent oxidoreductase
	catalyze the reduction of many endogenous and xenobiotic carbonyl compounds, including steroids and prostaglandins
	minor role in xenobiotic metabolism for CBR3
	its expression is induced under inflammatory conditions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

CBR3 is a new member of the NFE2L2 gene battery

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	NADPH

protein

target gene of NFE2L2, a cellular sensor of oxidative stress

cell & other

REGULATION

Other

regulated by the master redox switch NFE2L2

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to interindividual variability in the disposition of CBR drug substrates to type 2 diabetes and insulin resistance

Variant & Polymorphism other	common CBR3 V244M polymorphism encodes for CBR3 isoforms with distinctive enzymatic properties
	rs10483032 in the CBR3 (carbonyl reductase 3) gene, associated with type 2 diabetes

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS