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FLASH GENE
Symbol CBR3 contributors: npt/mct - updated : 10-09-2014
HGNC name carbonyl reductase 3
HGNC id 1549
DNA
TYPE functioning gene
STRUCTURE 11.59 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure
  • two potential NFKB (nuclear-factor kappa-B) consensus motifs were identified in the 5prime-UTR of the CBR3 gene which are located &
    • 8722;1160 and &
    8722;593 basepairs upstream of the transcriptional start site
  • a conserved antioxidant response element (ARE) in the promoter of human carbonyl reductase 3 (CBR3) mediates induction by the master redox switch NFE2L2
  • putative binding sites for various transcription factors, some additional environmental conditions may be involved in the regulation of CBR3 as well
    • MAPPING cloned Y linked N status confirmed
    regionally located located 62kb telomeric of CBR1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1128 30 277 - 1998 9740676
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
     salivary gland   highly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Cbr3
    homolog to C.elegans F54F3.4
    intraspecies paralog to CBR1
    Homologene
    FAMILY
  • short chain dehydrogenase/reductase (SDR) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • carbonyl reductase, NADPH-dependent oxidoreductase
  • catalyze the reduction of many endogenous and xenobiotic carbonyl compounds, including steroids and prostaglandins
  • minor role in xenobiotic metabolism for CBR3
  • its expression is induced under inflammatory conditions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • CBR3 is a new member of the NFE2L2 gene battery
    • INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein
  • target gene of NFE2L2, a cellular sensor of oxidative stress
    • cell & other
    REGULATION
    Other regulated by the master redox switch NFE2L2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to interindividual variability in the disposition of CBR drug substrates
  • to type 2 diabetes and insulin resistance
    • Variant & Polymorphism other
  • common CBR3 V244M polymorphism encodes for CBR3 isoforms with distinctive enzymatic properties
  • rs10483032 in the CBR3 (carbonyl reductase 3) gene, associated with type 2 diabetes
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS