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FLASH GENE
Symbol MSH5 contributors: mct - updated : 30-03-2021
HGNC name mutS homolog 5 (E. coli)
HGNC id 7328
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CRM1-dependent nuclear export signal (NES)
  • a nuclear localization signal that participates to its nuclear targeting
    • mono polymer heteromer , oligo
    HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae meiosis-specific protein
    ortholog to murine Msh5
    homolog to C.elegans H26D21.2
    homolog to rattus Rn.44043
    Homologene
    FAMILY DNA mismatch repair MUTS family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • MSH5 shuttles between the nucleus and the cytoplasm, being much less stable in the nucleus than in the cytoplasm
    • basic FUNCTION
  • putatively required for chromosome pairing in meiosis and DNA replicative mismatch repair
  • gonadal maintenance in females
  • involved in Mt DNA metabolism
  • facilitating crossovers between homologs during meiosis
  • playing functional roles in an array of cellular processes such as DNA damage response and meiotic homologous recombination
  • involved in DNA mismatch repair (MMR) and meiotic recombination, and deficiency of MMR has been documented to have a role in lung cancer (Wang 2008)
  • MutS-homologous protein required for meiotic DNA recombination
  • MSH5 implicated in homologous recombination (HR)-mediated DSB repair and the DNA damage response
  • MSH5 promotes HR-based DSB repair, and this property resides in the carboxyl-terminal portion of the protein
    • CELLULAR PROCESS cell cycle,division,meiosis
    nucleotide, recombination
    nucleotide, repair, mismatch repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterooligomer of MSH4 and MSH5
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • binding to MSH4
  • role for MSH5 in DNA damage response involving ABL1 and TP73, suggesting that mutations impairing this process could significantly affect normal cellular responses to anti-cancer treatments
  • MSH5 stimulates mtDNA repair in response to DNA damage induced by oxidative stress
  • functional interplay between MSH5 and BRIP1 in double-strand break repair induced by replication stress
  • MSH5 is the target of HCP5 during DNA double-strand breaks (DSBs) repair
  • HCP5 regulated MSH5 expression and Granulosa cells function through direct binding with YBX1 and modulating its subcellular localization
    • cell & other
    REGULATION
    activated by HCP5, that is a novel transcriptional activator of MSH5
    ASSOCIATED DISORDERS
    corresponding disease(s) POF13
    Susceptibility
  • to lung cancer
  • to azoospermia or oligozoospermia
    • Variant & Polymorphism other
  • variant rs3131379 in intron 10 associated to lung cancer (Wang 2008)
  • (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Msh5 null mutation mouse