Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | MSH5 | contributors: mct - updated : 30-03-2021 |
HGNC name | mutS homolog 5 (E. coli) |
HGNC id | 7328 |
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DNA |
TYPE | functioning gene |
STRUCTURE | 22.67 kb 25 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter (CAAT box) (TATA box) |
cytosine-phosphate-guanine/HTF | |
text structure | |
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MAPPING | cloned | Y | linked | Y | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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mono polymer | heteromer , oligo |
HOMOLOGY |
interspecies | ortholog to yeast S.cerevisiae meiosis-specific protein |
ortholog to murine Msh5 | |
homolog to C.elegans H26D21.2 | |
homolog to rattus Rn.44043 |
Homologene |
FAMILY | DNA mismatch repair MUTS family |
CATEGORY | DNA associated |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm | |
intracellular,nucleus,chromatin/chromosome | |
text |
basic FUNCTION | |
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CELLULAR PROCESS | cell cycle,division,meiosis |
nucleotide, recombination | |
nucleotide, repair, mismatch repair |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule | nucleotide, |
ATP |
protein | |
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cell & other |
REGULATION |
activated by | HCP5, that is a novel transcriptional activator of MSH5 |
ASSOCIATED DISORDERS |
corresponding disease(s) | POF13 |
Susceptibility |
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Variant & Polymorphism other | |
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |