protein
| activator of MAP3K7 (TAK1) leading to NF |
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activating MAPK14 (p38 alpha MAP kinase) |
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binds MAP3K7 and polyubiquitin chains to promote specific sites of phosphorylation in MAP3K7-MAP3K7IP1, which activates IKK signaling to NF-kappaB |
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KCNJ6/MAP3K7IP1 interaction is crucial for BIRK4-induced MAP3K7 and NF-kappaB activation |
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constitutively associated with MAP3K7 through its C-terminal region |
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relationship between two central regulatory pathways in which MAP3K7-MAP3K7IP1-TAB2 selectively induces calcineurin-NFAT signalling through direct phosphorylation of RCAN1, while calcineurin activation diminishes MAP3K7 signalling by dephosphorylation of MAP3K7 and MAP3K7IP1 |
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POSTN is involved in the suppression of cell invasiveness via the TAB1/MAP3K7 signaling pathway |
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regulatory subunit of MAP3K7, which functions upstream in the pathways activated by interleukin IL1, tumor necrosis factor (TNF), toll-like receptors (TLRs) and stressors |
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directly interacted with MAP3K7-binding protein 1 (TAB1) and dephosphorylated TAB1 at Ser(438), leading to TAB1-MAP3K7 complex inactivation in T cells |
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RNF4 interacts with the NR2C2-TAB2-TAB3 complex, but not TAB1 |