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FLASH GENE
Symbol KIF1C contributors: mct/npt/shn - updated : 21-06-2013
HGNC name kinesin family member 1C
HGNC id 6317
Location 17p13.2      Physical location : 4.901.242 - 4.931.693
Synonym name
  • cDNA sequence, expressed in brain, 80kDa, kinesin-like motor protein KIF1 c
  • LTXS1 mouse homolog of
  • kinesin-like protein KIF1C
  • Synonym symbol(s) KIAA0706, LTXS1
    DNA
    TYPE functioning gene
    STRUCTURE 26.72 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure
  • conserved essential regulatory element in the kinesin-1 tail interacts directly and specifically with the enzymatically critical Switch I region of the head
  • MAPPING cloned Y linked N status provisional
    Map pter - D17S1828 - D17S1584 - KIF1C - D17S1810 - D17S1854 - cen
    Physical map
    PELP1 17p13.3 similar to DTFT5783 LOC390758 17 similar to 40S RIBOSOMAL PROTEIN S12 ARRB2 17p13 arrestin, beta 2 CXCL16 17p13 chemokine (C-X-C motif) ligand 16 LOC388322 17 similar to HSPC296 ZMYND15 17p13.3 zinc finger, MYND domain containing 15 TM4SF5 17p13.3 transmembrane 4 superfamily member 5 LOC284013 17p13.3 secretory protein LOC284013 LOC388323 17 similar to RIKEN cDNA C730027E14 PSMB6 17p13 proteasome (prosome, macropain) subunit, beta type, 6 PLD2 17p13.1 phospholipase D2 LOC284015 17p13.3 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit MINK 17p13 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit CHRNE 17p13.1 cholinergic receptor, nicotinic, epsilon polypeptide GP1BA 17pter-p12 glycoprotein Ib (platelet), alpha polypeptide SLC25A11 17p13.3 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 DKFZP566H073 17p13.3 DKFZP566H073 protein PFN1 17p13.3 profilin 1 ENO3 17pter-p12 enolase 3, (beta, muscle) SPAG7 17p13.2 sperm associated antigen 7 CAMTA2 17p13.3 calmodulin binding transcription activator 2 LOC388324 17 LOC388324 KIF1C 17p13 kinesin family member 1C FLJ10060 17p13.3 putative G-protein coupled receptor GPCR42 FLJ30726 17p13.3 hypothetical protein FLJ30726 ZNF232 17p13-p12 zinc finger protein 232 USP6 17q11 ubiquitin specific protease 6 (Tre-2 oncogene) KIAA1871 17p13 KIAA1871 protein LOC388325 17 similar to DTFT5783 RABEP1 17p13.1 rabaptin, RAB GTPase binding effector protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 7935 135 1103 - - 9685376
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiensAdultNM_006612
    Digestiveliver   lowly Homo sapiensAdultNM_006612
    Endocrinepancreas   moderately Homo sapiensAdultNM_006612
    Nervousbrain   lowly Homo sapiensAdultNM_006612
    Reproductivefemale systemplacenta  moderately Homo sapiensAdultNM_006612
    Respiratorylung   lowly Homo sapiensAdultNM_006612
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly Homo sapiensAdultNM_006612
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a FHA domain
  • N terminal motor domain
  • PTPD-binding domain
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Kif1c
    homolog to C.elegans M116.5
    intraspecies homolog to kinesin-like motor protein KIF1 c
    Homologene
    FAMILY
  • Kinesin-3 family
  • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    text Golgi apparatus and endoplasmic reticulum
    basic FUNCTION
  • act as microtubule-based molecular motors involved in intracellular transport
  • podosome regulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTPD1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • kif1C(-/-) mice are viable and showed no obvious abnormalities
  • no significant difference in the distribution of the Golgi apparatus or in the transport from the Golgi apparatus to the endoplasmic reticulum in fibroblasts from kif1C(-/-) mice
  • Expression of mutation constructs or small interfering RNA-/short hairpin RNA-based depletion of KIF1C resulted in decreased podosome dynamics and ultimately in podosome deficiency