SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,nucleus
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| intracellular,nuclear envelope,pore
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| basic FUNCTION
| playing a role associated with cell cycle independent microtubule dynamics |
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evolutionary conserved motor-adaptor protein, is implicated in dynein-mediated transport as a molecular linker between the dynein motor and various cargos |
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cytoplasmic conserved motor-adaptor protein involved in anterograde and retrograde transport |
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has roles in the synaptic vesicle and membrane traffic and Golgi structure  |
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essential in dynein-dynactin microtubule transport, in clathrin-mediated synaptic-vesicular recycling, and in the Golgi network, and crucial for the functional integrity of lower motor neurons |
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its function is essential for motor neuron physiology |
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key adaptor protein that interacts with the dynein-dynactin motor complex, which facilitates trafficking of cellular cargos that are critical to motor neuron development and maintenance |
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essential non-cell-autonomous role of BICD2 in neuronal cell migration, which might be connected to cargo trafficking pathways in glia cells |
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joins dynein with dynactin into a ternary complex (termed DDB) capable of processive movement |
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BICD2 facilitates infection by promoting the trafficking of HIV viral cores to the nucleus, thereby promoting nuclear entry of the viral genome and infection |
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highly conserved motor adaptor protein that regulates the dynein-dynactin complex in different cellular processes |
