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FLASH GENE
Symbol CSTF2T contributors: mct - updated : 19-01-2016
HGNC name cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
HGNC id 17086
Location 10q21.1      Physical location : 53.455.246 - 53.459.355
Synonym name
  • like ortholog of mouse variant polyadenylation protein CSTF-64
  • cDNA sequence, expressed in brain, 60kDa, related to cleavage stimulation factor 64 kDa subunit
  • CF-1 64 kDa subunit, tau variant
  • Synonym symbol(s) KIAA0689, DKFZp434C1013, CstF-64T, TauCstF-64
    DNA
    TYPE functioning gene
    STRUCTURE 4.11 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    alternative promoter
    text structure alternatively polyadenylated in some tissues
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4127 64.3 616 - 2013 24149845
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Cardiovascularheart    
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage germ cells
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal RNA binding motif (RNA recognition motif)
  • HOMOLOGY
    interspecies ortholog to murine Cstf-64
    intraspecies homolog to cleavage stimulation factor 64 kDa subunit
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text expressed during meiosis and subsequent haploid differentiation
    basic FUNCTION
  • playing an essential role for normal transcription during meiosis
  • promotes germ-cell-specific patterns of polyadenylation by binding to different downstream sequence elements
  • CSTF2, CSTF2T differ in their affinities for specific RNA sequences, and the region C-terminal to the RBDs (RNA-binding domains) is mportant in RNA sequence recognition
  • required not only for expression of genes involved in morphological differentiation of spermatids but also for genes having products that function during interaction of motile spermatozoa with eggs
  • necessary for spermatogenesis and fertilization
  • its function is primarily to support spermatogenesis, but only incidentally to support immune cell function
  • plays likely a role in 3prime end determination and transcription termination for a large range of germ cell-expressed genes
  • functional overlap and specificity of CSTF2, CSTF2T mRNA 3 prime processing factors and provided new insights into the regulatory mechanisms of mRNA 3 prime processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions between CSTF2/CSTF2T and CSTF3 are important for the maintenance of stoichiometric nuclear levels of the CSTF complex components and for their intracellular localization, stability, and function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    loss of polyadenylation protein CSTF2T causes spermatogenic defects and male infertility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • spermatozoa from Cstf2t null mutant (Cstf2t(-/-)) mice of ages ranging from 60 to 108 days postpartum exhibited severe defects in motility and morphology that were correlated with a decrease in numbers of round spermatids