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FLASH GENE
Symbol HLF contributors: SGE/npt - updated : 10-06-2010
HGNC name hepatic leukemia factor
HGNC id 4977
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver   highly
Lymphoid/Immunethymus   highly
Nervousbrain   highly
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BZIP domain
    • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Hlf (97.6pc)
    homolog to Rattus Rn.21134
    homolog to C.elegans K02F3.4
    Homologene
    FAMILY
  • bZIP family
  • PAR subfamily
    • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may play a role in the function of differnetiated neurons in the adult nervous system rather than programmed cell death (Hitzler 1999)
    • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer or heterodimer with other PAR factors
    • INTERACTION
    DNA
  • binding to double-stranded DNA
  • binding sequence-specific promoter elements to activate transcription
    • RNA
    small molecule
    protein
  • CSTF2 is central to the function of HLF and appears to be at least partly responsible for its cell cycle regulation
    • cell & other
    REGULATION
    activated by thyroid hormone receptor beta/retinoid X receptor alpha, and thus increasing HIF1A gene expression (Otto 2008)
    Other accumulating according to a robust circadian rythm
    ASSOCIATED DISORDERS
    corresponding disease(s) HLF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    rearranged in acute B-cell leukemia, with translocation t(17;19)(q22;p13) and fusion with TCF3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS