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FLASH GENE
Symbol DZIP3 contributors: mct - updated : 16-12-2014
HGNC name DAZ interacting protein 3, zinc finger
HGNC id 30938
Location 3q13.13      Physical location : 108.308.336 - 108.413.692
Synonym name
  • cDNA sequence, expressed in brain, >100kDa, related to TPR repeat protein O
  • KIAA0675 gene product
  • UURF2 ubiquitin ligase
  • zinc finger DAZ interacting protein 3
  • human RNA-binding ubiquitin ligase of 138 kDa
  • Synonym symbol(s) KIAA0675, UURF2, hRUL138, FLJ13327, PPP1R66
    DNA
    TYPE functioning gene
    STRUCTURE 105.36 kb     33 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC344593 3q13.12 similar to protein tyrosine phosphatase, non-receptor type 11; protein-tyrosine phosphatase 2C; Noonan syndrome 1 LOC344595 3q13.12 hypothetical LOC344595 LOC391563 3 similar to citrate synthase (51.5 kD) (3L304) NYD-SP17 3q13.12 testes development-related NYD-SP17 BBX 3q13.1 bobby sox homolog (Drosophila) LOC285205 3q13.12 hypothetical protein LOC285205 CD47 3q13.1-q13.2 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) ESRRBL1 3q13.13 estrogen-related receptor beta like 1 HHLA2 3q13.13 HERV-H LTR-associating 2 KIAA1000 3q13.13 HERV-H LTR-associating 2 KIAA1524 3q13.13 KIAA1524 protein DZIP3 3q13.1-q13.2 KIAA1524 protein RETNLB 3q13.1 resistin like beta TRIM 3q13 resistin like beta GUCA1C 3q13.1 guanylate cyclase activator 1C MORC 3q13 microrchidia homolog (mouse) LOC151871 3q13.13 hypothetical protein BC018070 DPPA4 3q13.13 developmental pluripotency associated 4 LOC391564 3 similar to H3 histone, family 3B LOC391565 3 similar to peptidyl-Pro cis trans isomerase LOC389140 3 similar to Nuclear transcription factor Y subunit beta (NF-Y protein chain B) (NF-YB) (CCAAT-binding transcription factor subunit A) (CBF-A) (CAAT-box DNA binding protein subunit B) LOC389141 3 similar to laminin receptor 1 (ribosomal protein SA); P40-3, functional; P40-8, functional; laminin receptor 1 (67kD, ribosomal protein SA) LOC151760 3q13.13 hypothetical LOC151760 PVRL3 3q13 hypothetical LOC151760
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    33 - 5568 138 1208 - 2003 12538761
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to PR repeat protein O
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • the combined presence of RNA binding and E3 activity in DZIP3 raises the possibility that both are mechanistically linked
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, DZIP3 and MEX3B, as well as with their respective ubiquitination substrates, ATXN1 and SNUPN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS