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FLASH GENE
Symbol CHRNB2 contributors: npt/ - updated : 05-03-2007
HGNC name cholinergic receptor, nicotinic, beta 2 (neuronal)
HGNC id 1962
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large N terminal extracellular domain
  • four transmembrane segments (4TM) with the M2 domain comprising the cation-selective pore
  • 25 AA signal peptide
    • mono polymer heteromer , pentamer
    HOMOLOGY
    interspecies ortholog to murine Chrnb2
    Homologene
    FAMILY
  • cholinergic receptor family
  • ligand gated ion channel family
    • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having nicotinic acetylcholine-activated cation-selective channel activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heteropentamer alpha 4(2) beta 2 (3 subunits)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ENFL3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    ADNFLE mouse model harboring the V287L missense mutation of the CHRNB2 subunit (Manfredi 2009)