| basic FUNCTION
| SNAP91 and PICALM function as endocytic accessory proteins at synapses, but each may regulate distinct clathrin pathways  |
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required for the proper assembly of synaptic vesicles via clathrin-mediated endocytosis |
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SNAP91 and PICALM play critical roles in establishing the polarity and controlling the growth of axons and dendrites in embryonic hippocampal neurons |
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having functions in intracellular trafficking that are essential in the growth of neurons |
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SNAP91 and PICALM, while similar in their domain structures and biochemical properties, are in fact dedicated to separate trafficking pathways in neurons |
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its function in retrieving surface-stranded synaptobrevin from the neuronal surface may be related to its role in neurodegenerative disorders, including Alzheimer disease |
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its levels and synaptic distribution are highly sensitive to neuronal activity |
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involved in the assembly of clathrin coated vesicles in synaptic vesicle endocytosis |
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SNAP91 and PICALM are cargo-specific adaptors for synaptobrevin endocytosis, in the central nervous system |
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SNAP91 and PICALM not only regulate the assembly of the endocytic machinery but also act as sorters for a subset of SNAREs, the vesicle-associated membrane proteins (VAMPs), most notably VAMP/synaptobrevin 2 at synapses |
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SNAP91 and PICALM regulate the assembly of clathrin-coated vesicles (CCVs), which mediate diverse intracellular trafficking processes, including synaptic vesicle (SV) recycling at the synapse |
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SNAP91 and PICALM in the presynaptic terminals of hippocampal neurons, have a similar role in regulating synaptic vesicles |
