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FLASH GENE

Symbol

SNAP91

contributors: mct - updated : 30-06-2012

HGNC name	synaptosomal-associated protein, 91kDa homolog (mouse)
HGNC id	14986

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	156.52 kb     28 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014841 30 - 4465 NP_055656 92.5 907 - 2011 21808019 CALM NM_001242794 20 - 3340 NP_001229723 63.1 600 - 2011 21808019 NM_001242793 28 - 4171 NP_001229722 89.7 877 - 2011 21808019 NM_001242792 30 - 4462 NP_001229721 - 907 - 2011 21808019 NM_001256717 - - 4529 NP_001243646 83.4 816 - 2011 21808019 NM_001256718 - - 4157 NP_001243647 78.6 783 - 2011 21808019

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an ANTH domain, required and sufficient for VAMP2 association

HOMOLOGY

interspecies	homolog to rattus clathrin assembly protein AP180 short form
	homolog to murine Snap91

Homologene

FAMILY

AP180 family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	SNAP91 and PICALM function as endocytic accessory proteins at synapses, but each may regulate distinct clathrin pathways
	required for the proper assembly of synaptic vesicles via clathrin-mediated endocytosis
	SNAP91 and PICALM play critical roles in establishing the polarity and controlling the growth of axons and dendrites in embryonic hippocampal neurons
	having functions in intracellular trafficking that are essential in the growth of neurons
	SNAP91 and PICALM, while similar in their domain structures and biochemical properties, are in fact dedicated to separate trafficking pathways in neurons
	its function in retrieving surface-stranded synaptobrevin from the neuronal surface may be related to its role in neurodegenerative disorders, including Alzheimer disease
	its levels and synaptic distribution are highly sensitive to neuronal activity
	involved in the assembly of clathrin coated vesicles in synaptic vesicle endocytosis
	SNAP91 and PICALM are cargo-specific adaptors for synaptobrevin endocytosis, in the central nervous system
	SNAP91 and PICALM not only regulate the assembly of the endocytic machinery but also act as sorters for a subset of SNAREs, the vesicle-associated membrane proteins (VAMPs), most notably VAMP/synaptobrevin 2 at synapses
	SNAP91 and PICALM regulate the assembly of clathrin-coated vesicles (CCVs), which mediate diverse intracellular trafficking processes, including synaptic vesicle (SV) recycling at the synapse
	SNAP91 and PICALM in the presynaptic terminals of hippocampal neurons, have a similar role in regulating synaptic vesicles

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

stable association of PLCG1 with SNAP91 in a clathrin-coated vesicle complex, which not only binds to the C-terminal SH2 domain of PLCG1, but also inhibits its enzymatic activity in a dose-dependent manner

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS