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FLASH GENE
Symbol SNAP91 contributors: mct - updated : 30-06-2012
HGNC name synaptosomal-associated protein, 91kDa homolog (mouse)
HGNC id 14986
Location 6q14.2      Physical location : 84.262.606 - 84.419.127
Synonym name
  • cDNA sequence, expressed in brain, >100kDa, rat clathrin assembly protein AP180 short form homolog
  • clathrin coat assembly protein AP180
  • assembly protein, 180kDa
  • clathrin assembly lymphoid myeloid leukemia
    • Synonym symbol(s) KIAA0656, AP180, CALM, DKFZp781O0519
    DNA
    TYPE functioning gene
    STRUCTURE 156.52 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 4465 92.5 907 - 2011 21808019
    CALM
    20 - 3340 63.1 600 - 2011 21808019
    28 - 4171 89.7 877 - 2011 21808019
    30 - 4462 - 907 - 2011 21808019
    - - 4529 83.4 816 - 2011 21808019
    - - 4157 78.6 783 - 2011 21808019
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ANTH domain, required and sufficient for VAMP2 association
    • HOMOLOGY
    interspecies homolog to rattus clathrin assembly protein AP180 short form
    homolog to murine Snap91
    Homologene
    FAMILY AP180 family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • SNAP91 and PICALM function as endocytic accessory proteins at synapses, but each may regulate distinct clathrin pathways
  • required for the proper assembly of synaptic vesicles via clathrin-mediated endocytosis
  • SNAP91 and PICALM play critical roles in establishing the polarity and controlling the growth of axons and dendrites in embryonic hippocampal neurons
  • having functions in intracellular trafficking that are essential in the growth of neurons
  • SNAP91 and PICALM, while similar in their domain structures and biochemical properties, are in fact dedicated to separate trafficking pathways in neurons
  • its function in retrieving surface-stranded synaptobrevin from the neuronal surface may be related to its role in neurodegenerative disorders, including Alzheimer disease
  • its levels and synaptic distribution are highly sensitive to neuronal activity
  • involved in the assembly of clathrin coated vesicles in synaptic vesicle endocytosis
  • SNAP91 and PICALM are cargo-specific adaptors for synaptobrevin endocytosis, in the central nervous system
  • SNAP91 and PICALM not only regulate the assembly of the endocytic machinery but also act as sorters for a subset of SNAREs, the vesicle-associated membrane proteins (VAMPs), most notably VAMP/synaptobrevin 2 at synapses
  • SNAP91 and PICALM regulate the assembly of clathrin-coated vesicles (CCVs), which mediate diverse intracellular trafficking processes, including synaptic vesicle (SV) recycling at the synapse
  • SNAP91 and PICALM in the presynaptic terminals of hippocampal neurons, have a similar role in regulating synaptic vesicles
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stable association of PLCG1 with SNAP91 in a clathrin-coated vesicle complex, which not only binds to the C-terminal SH2 domain of PLCG1, but also inhibits its enzymatic activity in a dose-dependent manner
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS