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FLASH GENE

Symbol

ICOSLG

contributors: mct - updated : 02-01-2017

HGNC name	inducible T-cell co-stimulator ligand
HGNC id	17087

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

Icosl -/- mice are healthy and fertile but have a reduced IgG1 production and affinity maturation, indicating a defect in T cell responses. Also have impaired T and B-cell interaction and germinal center formation