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FLASH GENE

Symbol

ICOSLG

contributors: mct - updated : 02-01-2017

HGNC name	inducible T-cell co-stimulator ligand
HGNC id	17087

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in patients with systemic lupus erythematosus constitutional     --over   of ICOS and ICOSLG in Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and vasculitic neuropathy (VN) vs patients with hereditary neuropathies (HNs)

Susceptibility

to Crohn disease

Variant & Polymorphism other	rs7282490 ICOSLG GG risk carriers associated with an ileal Crohn disease phenotype

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Icosl -/- mice are healthy and fertile but have a reduced IgG1 production and affinity maturation, indicating a defect in T cell responses. Also have impaired T and B-cell interaction and germinal center formation