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FLASH GENE
Symbol AGL contributors: mct/npt - updated : 18/09/2008
HGNC name amylo-1, 6-glucosidase, 4-alpha-glucanotransferase
HGNC id 321
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • alpha amylase catalytic domain
  • CBD (arbohydrate-binding domain) playing a major role to coordinate its functions and regulation by the ubiquitin–proteasome system (Cheng 2009)
  • C-terminal region binding to glycogen
  • two separate domains for the transferase and glucosidase activities
    • mono polymer monomer
    HOMOLOGY
    interspecies homolog to dog AGL (93.8 pc)
    homolog to rattus Agl (92.2 pc)
    homolog to murine Agl (91.8 pc)
    homolog to chicken AGL (81.7 pc)
    Homologene
    FAMILY
  • multifunctional enzyme
  • glycogen debranching enzyme family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as an amylo-1,6-glucosidase (4-alpha-glucantransferase) implicated in glycogen catabolism
  • acting as a 1,4-alpha-D-glucan : 1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
  • glycogen catabolism
  • glycogen biosynthesis
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding AMPK beta1-subunit (in mouse)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GSD3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS