SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome,centromere
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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| text
| colocalized with CLIPs at microtubule distal ends |
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during the mitosis, it localizes to centrosomes, the mitotic spindle, centromeres and spindle midzone |
| basic FUNCTION
| local regulation spindle microtubule dynamics and attachment to kinetochore |
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plays a role in centrosome separation and organisation of the bipolar mitotic spindle |
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required at kinetochores for attached microtubules to exhibit normal dynamic behavior |
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cooperate with CLASP2 to ensure mitotic fidelity by regulating spindle and kinetochore function |
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required for mitotic spindle organization and kinetochore alignment  |
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function as actin/microtubule crosslinkers in interphase cells and facilitate recognition of actin filaments by the plus ends of growing microtubules at the initial stages of actin-microtubule interaction |
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essential for Golgi-associated microtubule nucleation and directional migration |
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CLASP1 is required to correctly capture astral microtubules, whereas MAP4 prevents engagement of excess dynein motors, thereby protecting the system from force imbalance |
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MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis in human cells |
