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FLASH GENE
Symbol CLASP1 contributors: npt/shn/pgu - updated : 08-04-2010
HGNC name cytoplasmic linker associated protein 1
HGNC id 17088
DNA
TYPE functioning gene
STRUCTURE 311.70 kb     39 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D2S2265 - D2S2258 - CLASP1 - D2S343 - D2S2353 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
39 splicing 7941 - 1479 - 2003 12837247
38 splicing 7917 - 1471 - 2003 12837247
39 splicing 8118 - 1538 - 2003 12837247
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouth   highly
Lymphoid/Immunethymus   highly
Nervousbrain    
Reproductivefemale systembreastmammary gland highly
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six heat repeats
    • HOMOLOGY
    interspecies ortholog to clasp1, Danio rerio
    ortholog to Clasp1, Mus musculus
    ortholog to CLASP1, Pan troglodytes
    ortholog to Clasp1, Rattus norvegicus
    intraspecies homolog to CLASP2
    Homologene
    FAMILY
  • CLASP family
    • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • colocalized with CLIPs at microtubule distal ends
  • during the mitosis, it localizes to centrosomes, the mitotic spindle, centromeres and spindle midzone
    • basic FUNCTION
  • local regulation spindle microtubule dynamics and attachment to kinetochore
  • plays a role in centrosome separation and organisation of the bipolar mitotic spindle
  • required at kinetochores for attached microtubules to exhibit normal dynamic behavior
  • cooperate with CLASP2 to ensure mitotic fidelity by regulating spindle and kinetochore function
  • required for mitotic spindle organization and kinetochore alignment
  • function as actin/microtubule crosslinkers in interphase cells and facilitate recognition of actin filaments by the plus ends of growing microtubules at the initial stages of actin-microtubule interaction
  • essential for Golgi-associated microtubule nucleation and directional migration
  • CLASP1 is required to correctly capture astral microtubules, whereas MAP4 prevents engagement of excess dynein motors, thereby protecting the system from force imbalance
  • MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis in human cells
    • CELLULAR PROCESS cell cycle, division
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLIP2 and CLIP1, binding to microtubules and cooperate to direct the microtubule network and regulating cellular asymmetry
  • MAPRE1
  • interacting with GSK3A (controls axon growth via CLASP1-mediated regulation of growth cone microtubules)
  • estrogen receptor binding CpG island, EB1
  • PRC1 to the central spindle at early anaphase onset
  • is a substrate for the BRCA1, suggesting that its modification selectively triggers CHEK1 activation for the homology-directed repair of a subset of genotoxic lesions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS