SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,microsome
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| intracellular,cytoplasm,cytoskeleton
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text
| expressed in pseudopodia and in cytoplasm around the nucleus |
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colocalized with actin in the I-band |
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colocalizes with betaPS integrin in myotendinous junctions and with alpha-actinin in muscle Z lines(Jani 2007) |
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cytoskeletal protein localized in the sarcomeric Z-line (Zheng 2009) |
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localized predominantly at Z-lines together with sarcomeric alpha-actinin |
basic FUNCTION
| Z-disc associated protein,that may function as an adaptor in striated muscle to couple protein kinase C-mediated signaling, via its LIM domains, to the cytoskeleton (alpha-actinin-2) through its PDZ domain |
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has an important role in maintaining Z-disc stability in striated and cardiac muscle (Klaavuniemi 2006) |
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striated Z-line protein, which plays an important structural role in cardiac muscle in maintaining the integrity of sarcomeres under the stress of contraction force |
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important function in the assembly of integrin adhesion sites both in cell culture and in tissues (Jani 2007) |
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plays a pivotal role in maintaining adult cardiac structure and cardiac function through protein–protein interactions with other Z-line proteins (Zheng 2009) |
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having a pivotal role in the structure and functions of striated muscles (Zheng 2009) |
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plays an essential structural role in cardiac muscle |
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cytoskeletal protein that forms multiprotein complexes at sarcomeric Z-lines |
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not only plays a structural role for the sarcomeric integrity, but is also an important sarcomeric signaling scaffold in regulating the phosphorylation of channels or contractile proteins |
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LDB3 and PDLIM5 redundantly play an essential role in sustaining Z-line structure from the earliest stages of cardiac function, and are redundantly required to maintain normal embryonic heart function and embryonic viability |