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FLASH GENE

Symbol

FAS

contributors: mct/ - updated : 05-03-2016

HGNC name	Fas (TNF receptor superfamily, member 6)
HGNC id	11920

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CSS1 , TAL4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       fusion with ESR1 in several cancer lines (prostate, breast cervical, bladder) tumoral somatic mutation       mutated in the death domain in the non small cell lung cancer, in non lymphoid malignancie, T cell lymphoma and Hodgkin's disease, thyroid lymphoma, nasal NK/T cell lymphoma tumoral       loss of function retention of intron 5 and encodes a dysfunctional protein impairment of Fas-induced apoptosis resulting from aberrant splicing potentially contributes to the development and progression of cutaneous T-cell lymphoma tumoral somatic mutation       in nodal diffuse large B-cell lymphoma tumoral     --over   in epithelial ovarian cancer

Susceptibility

implicated early-onset Alzheimer with inconsistant results to autoimmune diabetes systemic lupus erythematous with loss of regulation of B lymphocytes to acute myeloid leukemia (AML) to myocardial infarction (MI)

Variant & Polymorphism SNP , other	promoter playing a role in Alzheimer disease
	increased risk of AML associated with heterozygotes (GA) and homozygote variants (AA) at position -1377 bp
	SNP (-670G/A), may be a risk factor of MI occurrence

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     locking FAS in apoptosis-mode may be a more promising anti-cancer strategy than simply inhibiting or stimulating FAS

ANIMAL & CELL MODELS